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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alternativeName
|
PCGF4
Polycomb group RING finger protein 4
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gptkbp:associatedWith
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gptkb:cancer
|
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gptkbp:discoveredBy
|
van Lohuizen et al.
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gptkbp:disease_involvement
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
leukemia
prostate cancer
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gptkbp:domain
|
RING finger domain
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gptkbp:encodedBy
|
BMI1 gene
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gptkbp:Entrez_Gene_ID
|
648
ENSP00000362431
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gptkbp:expressedIn
|
various tissues
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gptkbp:family
|
Polycomb group protein
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gptkbp:firstDescribed
|
1991
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gptkbp:function
|
regulation of gene expression
transcriptional repressor
component of Polycomb Repressive Complex 1 (PRC1)
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gptkbp:GO_term
|
GO:0005634 (nucleus)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0016571 (histone ubiquitination)
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|
https://www.w3.org/2000/01/rdf-schema#label
|
BMI1 (human)
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gptkbp:interactsWith
|
gptkb:CBX_proteins
gptkb:RING1A
gptkb:RING1B
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gptkbp:involvedIn
|
cell proliferation
chromatin modification
oncogenesis
stem cell self-renewal
|
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gptkbp:locatedOnChromosome
|
10p12.2
|
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gptkbp:location
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gptkb:nucleus
|
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gptkbp:molecularWeight
|
37 kDa
|
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gptkbp:organism
|
gptkb:Homo_sapiens
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gptkbp:orthologIn
|
Bmi1 (mouse)
Bmi1 (rat)
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gptkbp:overexpressedIn
|
cancer stem cells
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gptkbp:PDB
|
6H3C
|
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gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
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gptkbp:RefSeq
|
NP_005169
|
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gptkbp:regulates
|
gptkb:p14ARF
gptkb:p16INK4a
INK4a/ARF locus
|
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gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
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gptkbp:UniProtID
|
P35226
|
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gptkbp:bfsParent
|
gptkb:Posterior_sex_combs_(Psc)
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gptkbp:bfsLayer
|
8
|