BCL2 Associated X, Apoptosis Regulator

URI: https://gptkb.org/entity/BCL2_Associated_X,_Apoptosis_Regulator
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:BAX
gptkbp:apoptosisPathway intrinsic pathway
gptkbp:discoveredIn 1993
gptkbp:encodedBy BAX gene
gptkbp:Entrez_Gene_ID 581
gptkbp:function promotes apoptosis
https://www.w3.org/2000/01/rdf-schema#label BCL2 Associated X, Apoptosis Regulator
gptkbp:inducedBy cytochrome c release
gptkbp:interactsWith gptkb:BCL-XL
gptkb:BCL2
gptkbp:locatedOnChromosome gptkb:chromosome_19
19q13.33
gptkbp:location mitochondrial outer membrane
gptkbp:memberOf BCL2 protein family
gptkbp:molecularWeight 21 kDa
gptkbp:mutationAssociatedWith tumorigenesis
gptkbp:OMIM 600040
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:1F16
gptkbp:regulates upregulated by p53
mitochondrial membrane permeability
gptkbp:role gptkb:cancer
neurodegenerative diseases
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure contains BH1 domain
contains BH2 domain
contains BH3 domain
gptkbp:UniProtID gptkb:Q07812
gptkbp:bfsParent gptkb:BAX
gptkbp:bfsLayer 6