Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:CD276
|
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:cellSurfaceMarker |
yes
|
| gptkbp:discoveredIn |
2001
|
| gptkbp:encodedBy |
CD276 gene
|
| gptkbp:Entrez_Gene_ID |
80381
|
| gptkbp:expressedIn |
various human tissues
|
| gptkbp:function |
immune checkpoint molecule
modulates T-cell responses |
| gptkbp:glycosylation |
heavily glycosylated
|
| gptkbp:HGNC_ID |
HGNC:17046
|
| https://www.w3.org/2000/01/rdf-schema#label |
B7-H3
|
| gptkbp:interactsWith |
gptkb:NK_cells
gptkb:T_cells |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_15
|
| gptkbp:memberOf |
gptkb:B7_family
|
| gptkbp:molecularWeight |
~50-100 kDa
|
| gptkbp:overexpressedIn |
several cancers
|
| gptkbp:potentialTargetFor |
immunotherapy
|
| gptkbp:role |
angiogenesis
autoimmune diseases metastasis tumor immune evasion |
| gptkbp:structure |
type I transmembrane protein
|
| gptkbp:target |
monoclonal antibodies
|
| gptkbp:UniProtID |
gptkb:Q5ZPR3
|
| gptkbp:bfsParent |
gptkb:CD276
gptkb:B7_family gptkb:XQ-BT52 |
| gptkbp:bfsLayer |
8
|