Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
AmpC-type beta-lactamase
class C beta-lactamase |
| gptkbp:class |
Ambler class C beta-lactamase
|
| gptkbp:encodedBy |
plasmid
chromosomal gene |
| gptkbp:enzymeCommissionNumber |
3.5.2.6
|
| gptkbp:firstDescribed |
1979
|
| gptkbp:foundIn |
gptkb:Enterobacteriaceae
gptkb:Pseudomonas_aeruginosa gptkb:Bacteria gptkb:Klebsiella_pneumoniae |
| gptkbp:function |
hydrolyzes beta-lactam antibiotics
|
| https://www.w3.org/2000/01/rdf-schema#label |
AmpC beta-lactamase
|
| gptkbp:inhibitedBy |
gptkb:clavulanic_acid
gptkb:sulbactam tazobactam avibactam |
| gptkbp:mechanismOfAction |
hydrolysis of beta-lactam ring
|
| gptkbp:resistantTo |
gptkb:cephalosporins
penicillins beta-lactam/beta-lactamase inhibitor combinations |
| gptkbp:significance |
antibiotic resistance
|
| gptkbp:structure |
serine-based active site
|
| gptkbp:substrate |
penicillins
broad-spectrum cephalosporins cephamycins |
| gptkbp:bfsParent |
gptkb:Beta-lactamase
|
| gptkbp:bfsLayer |
7
|