|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
zinc ion
|
|
gptkbp:alternativeName
|
gptkb:ADH
gptkb:aldehyde_reductase
gptkb:ethanol_dehydrogenase
|
|
gptkbp:CASNumber
|
9031-72-5
|
|
gptkbp:catalyzes
|
oxidation of alcohols to aldehydes or ketones
|
|
gptkbp:cofactor
|
NADP+
NAD+
|
|
gptkbp:discoveredBy
|
gptkb:yeast
|
|
gptkbp:EC_number
|
1.1.1.1
|
|
gptkbp:encodedBy
|
gptkb:ADH1A
gptkb:ADH1B
gptkb:ADH1C
gptkb:ADH4
gptkb:ADH5
gptkb:ADH6
gptkb:ADH7
|
|
gptkbp:foundIn
|
gptkb:yeast
gptkb:Bacteria
humans
plants
|
|
gptkbp:hasRole
|
alcohol flush reaction
alcohol tolerance
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Alcohol dehydrogenase
|
|
gptkbp:inhibitedBy
|
gptkb:fomepizole
gptkb:4-methylpyrazole
gptkb:disulfiram
|
|
gptkbp:involves
|
ethanol metabolism
retinol metabolism
|
|
gptkbp:molecularWeight
|
~80 kDa (dimer)
|
|
gptkbp:mutationAssociatedWith
|
alcohol intolerance
increased risk of esophageal cancer
|
|
gptkbp:optimum_pH
|
7.5-9.0
|
|
gptkbp:PDB
|
gptkb:1HTB
1ADC
2JHF
|
|
gptkbp:presentIn
|
gptkb:cancer
gptkb:kidney
gptkb:testis
brain
gastrointestinal tract
liver
stomach
|
|
gptkbp:proteinFamily
|
gptkb:ADH
|
|
gptkbp:subunit
|
dimer
tetramer
|
|
gptkbp:systematicName
|
gptkb:alcohol:NAD+_oxidoreductase
|
|
gptkbp:used_in
|
gptkb:biotechnology
industrial fermentation
clinical toxicology
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|