|
gptkbp:instanceOf
|
gptkb:drug
gptkb:vitamin_A
|
|
gptkbp:approvalYear
|
1982
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:D10BA01
|
|
gptkbp:brand
|
gptkb:Accutane
gptkb:Absorica
gptkb:Roaccutane
gptkb:Amnesteem
gptkb:Claravis
gptkb:Sotret
|
|
gptkbp:CASNumber
|
gptkb:4759-48-2
|
|
gptkbp:chemicalFormula
|
C20H28O2
|
|
gptkbp:contraindication
|
pregnancy
breastfeeding
|
|
gptkbp:discoveredBy
|
gptkb:Hoffmann-La_Roche
|
|
gptkbp:drugClass
|
gptkb:vitamin_A
|
|
gptkbp:eliminationHalfLife
|
10-20 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
isotretinoin
|
|
gptkbp:IUPACName
|
gptkb:(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic_acid
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
1982
|
|
gptkbp:mechanismOfAction
|
decreases sebum production
reduces sebaceous gland size
regulates cell proliferation
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
300.44 g/mol
|
|
gptkbp:monitors
|
liver function tests
pregnancy tests
lipid profile
|
|
gptkbp:pregnancyCategory
|
X
|
|
gptkbp:pregnancyPreventionProgram
|
gptkb:iPLEDGE
|
|
gptkbp:prescribes
|
dermatologist
|
|
gptkbp:PubChem_CID
|
5282379
|
|
gptkbp:riskFactor
|
gptkb:depression
birth defects
liver toxicity
increased cholesterol
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
joint pain
muscle pain
teratogenicity
dry skin
nosebleeds
dry lips
|
|
gptkbp:UNII
|
EH28UP18IF
|
|
gptkbp:usedFor
|
severe acne
cystic acne
nodular acne
|
|
gptkbp:bfsParent
|
gptkb:ATRA
|
|
gptkbp:bfsLayer
|
6
|