|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:AMP
gptkb:ADP
phosphorylation at Thr172
|
|
gptkbp:alsoKnownAs
|
gptkb:AMP-activated_protein_kinase_catalytic_subunit_alpha-2
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:type_2_diabetes
gptkb:metabolic_syndrome
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
|
|
gptkbp:catalyticSubunitOf
|
gptkb:AMPK
|
|
gptkbp:component
|
gptkb:AMP-activated_protein_kinase_(AMPK)_complex
|
|
gptkbp:discoveredBy
|
gptkb:D._Grahame_Hardie
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
PRKAA2 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000162409
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
heart
liver
|
|
gptkbp:function
|
regulation of cellular energy homeostasis
|
|
gptkbp:gene
|
gptkb:PRKAA2
|
|
gptkbp:hasIsoform
|
AMPK1 (PRKAA1)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AMPK2
|
|
gptkbp:inhibitedBy
|
gptkb:ATP
|
|
gptkbp:involvedIn
|
AMPK signaling pathway
|
|
gptkbp:locatedOnChromosome
|
1p31
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
62 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4CFE
|
|
gptkbp:phosphorylates
|
multiple metabolic enzymes
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NM_006252
|
|
gptkbp:regulates
|
lipid metabolism
cell growth
glucose uptake
protein synthesis
autophagy
fatty acid oxidation
|
|
gptkbp:sequence
|
552 amino acids
|
|
gptkbp:subunit
|
AMPK heterotrimeric complex
|
|
gptkbp:target
|
gptkb:AICAR
gptkb:metformin
thienopyridone compounds
|
|
gptkbp:UniProtID
|
gptkb:Q9Y478
|
|
gptkbp:bfsParent
|
gptkb:PRKAA2
|
|
gptkbp:bfsLayer
|
7
|