AMP-activated protein kinase catalytic subunit alpha-2

URI: https://gptkb.org/entity/AMP-activated_protein_kinase_catalytic_subunit_alpha-2
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy gptkb:AICAR
gptkb:metformin
gptkb:AMP
gptkbp:alternativeName gptkb:AMPK_catalytic_subunit_alpha-2
AMPK alpha-2
PRKAA2 protein
gptkbp:associatedWith gptkb:cardiovascular_disease
gptkb:type_2_diabetes
gptkbp:biologicalProcess protein serine/threonine kinase activity
gptkbp:component gptkb:AMP-activated_protein_kinase_(AMPK)_complex
gptkbp:Entrez_Gene_ID 5563
gptkbp:enzymeCommissionNumber 2.7.11.31
gptkbp:expressedIn gptkb:skeletal_muscle
heart
liver
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of cellular energy homeostasis
catalytic subunit of AMPK
gptkbp:gene gptkb:PRKAA2
gptkbp:HGNC_ID 9386
https://www.w3.org/2000/01/rdf-schema#label AMP-activated protein kinase catalytic subunit alpha-2
gptkbp:inhibitedBy compound C (dorsomorphin)
gptkbp:interactsWith AMP-activated protein kinase beta subunit
AMP-activated protein kinase gamma subunit
gptkbp:involves AMPK signaling pathway
gptkbp:length 552
gptkbp:locatedOnChromosome 1p31
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 62 kDa
gptkbp:OMIM 600497
gptkbp:orthologInMouse gptkb:Prkaa2
gptkbp:PDB gptkb:4CFE
gptkbp:phosphorylates gptkb:CaMKKβ
gptkb:LKB1
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:RefSeq gptkb:NP_006243.2
gptkbp:regulates lipid metabolism
glucose uptake
autophagy
fatty acid oxidation
gptkbp:subunit AMPK heterotrimer
gptkbp:UniProtID gptkb:Q9Y478
gptkbp:bfsParent gptkb:PRKAA2
gptkbp:bfsLayer 7