ALK rearrangement

URI: https://gptkb.org/entity/ALK_rearrangement

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:genetic_alteration
gptkbp:associatedWith	gptkb:anaplastic_large_cell_lymphoma gptkb:non-small_cell_lung_cancer
gptkbp:cause	constitutive kinase activation
gptkbp:common_fusion_partner	gptkb:EML4 gptkb:TPM3 gptkb:NPM1
gptkbp:detects	gptkb:FISH gptkb:RT-PCR immunohistochemistry
gptkbp:firstDescribed	1994
gptkbp:involvedIn	gptkb:ALK
gptkbp:locatedOnChromosome	2p23
gptkbp:result	gptkb:protein
gptkbp:targetOfDrug	gptkb:alectinib gptkb:brigatinib gptkb:ceritinib gptkb:crizotinib gptkb:lorlatinib
gptkbp:bfsParent	gptkb:non-small_cell_lung_cancer gptkb:lung_adenocarcinoma gptkb:Lung_cancer_(non-small_cell) gptkb:NSCLC
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	ALK rearrangement