Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:OTC
|
| gptkbp:catalyzes |
conversion of ornithine and carbamoyl phosphate to citrulline
|
| gptkbp:deficiencyCauses |
ornithine transcarbamylase deficiency
|
| gptkbp:discoveredBy |
1950s
|
| gptkbp:EC_number |
2.1.3.3
|
| gptkbp:encodedBy |
gptkb:OTC_gene
|
| gptkbp:foundIn |
mitochondria
|
| https://www.w3.org/2000/01/rdf-schema#label |
ornithine transcarbamylase
|
| gptkbp:involves |
gptkb:urea_cycle
|
| gptkbp:locatedOnChromosome |
gptkb:X_chromosome_(Xp21.1)
|
| gptkbp:molecularWeight |
approximately 36 kDa (monomer)
|
| gptkbp:presentIn |
gptkb:small_intestine
liver |
| gptkbp:product |
phosphate
citrulline |
| gptkbp:requires |
ammonia detoxification
|
| gptkbp:significance |
mutations cause hyperammonemia
|
| gptkbp:structure |
homotrimer
|
| gptkbp:substrate |
ornithine
carbamoyl phosphate |
| gptkbp:bfsParent |
gptkb:urea_cycle
|
| gptkbp:bfsLayer |
5
|