carbamoyl phosphate synthetase I
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:catalyzes |
synthesis of carbamoyl phosphate from ammonia and bicarbonate
|
| gptkbp:cofactor |
gptkb:ATP
|
| gptkbp:compatibleWith |
cytosol
|
| gptkbp:deficiencyCauses |
hyperammonemia
|
| gptkbp:EC_number |
6.3.4.16
|
| gptkbp:foundIn |
liver
|
| gptkbp:gene |
gptkb:CPS1
|
| https://www.w3.org/2000/01/rdf-schema#label |
carbamoyl phosphate synthetase I
|
| gptkbp:involves |
gptkb:urea_cycle
|
| gptkbp:location |
mitochondria
|
| gptkbp:molecularWeight |
approximately 165 kDa
|
| gptkbp:not_involved_in |
pyrimidine biosynthesis
|
| gptkbp:OMIM |
237300
|
| gptkbp:product |
carbamoyl phosphate
|
| gptkbp:regulates |
activated by N-acetylglutamate
|
| gptkbp:requires |
N-acetylglutamate as an allosteric activator
|
| gptkbp:structure |
homotetramer
|
| gptkbp:substrate |
ammonia
bicarbonate |
| gptkbp:UniProtID |
gptkb:P31327
|
| gptkbp:bfsParent |
gptkb:urea_cycle
|
| gptkbp:bfsLayer |
5
|