|
gptkbp:instanceOf
|
gptkb:drug
opioid
|
|
gptkbp:approvalYear
|
2008
|
|
gptkbp:approvedBy
|
gptkb:Germany
|
|
gptkbp:ATCCode
|
N02AX06
|
|
gptkbp:availableOn
|
extended-release tablet
immediate-release tablet
|
|
gptkbp:brand
|
gptkb:Nucynta
gptkb:Palexia
|
|
gptkbp:broadcastOn
|
gptkb:Schedule_II_(US)
|
|
gptkbp:CASNumber
|
175591-23-8
|
|
gptkbp:contraindication
|
paralytic ileus
acute or severe bronchial asthma
severe respiratory depression
|
|
gptkbp:developedBy
|
gptkb:Grünenthal_GmbH
|
|
gptkbp:drugClass
|
analgesic
opioid
|
|
gptkbp:eliminationHalfLife
|
4 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C14H23NO
|
|
gptkbp:hasSMILES
|
CC[C@@H](C)[C@H](N(C)C)Cc1cccc(c1)O
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tapentadol
|
|
gptkbp:interactsWith
|
gptkb:MAO_inhibitors
gptkb:CNS_depressants
serotonergic drugs
|
|
gptkbp:IUPACName
|
3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
norepinephrine reuptake inhibitor
mu-opioid receptor agonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:overdoseSymptoms
|
death
coma
respiratory depression
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL2103837
8014014
9838023
|
|
gptkbp:riskFactor
|
respiratory depression
dependence
abuse potential
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
constipation
dizziness
somnolence
|
|
gptkbp:UNII
|
9EVU44QK53
|
|
gptkbp:usedFor
|
pain management
moderate to severe pain
|
|
gptkbp:bfsParent
|
gptkb:opioid_analgesics
|
|
gptkbp:bfsLayer
|
7
|