Statements (108)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
natural product alkaloid |
| gptkbp:alternativeName |
Alkaloid
alkali ergot_alkaloid indole_alkaloid tropane_alkaloid tryptamine_alkaloid xanthine_alkaloid |
| gptkbp:biosynthesized_from |
fungi
amino acids |
| gptkbp:canBeSynthesizedFrom |
tryptophan
|
| gptkbp:cause |
nausea
vomiting hypertension ergotism hallucinations gangrene convulsions uterine contractions vasospasm |
| gptkbp:class |
metabolite
heterocyclic compound |
| gptkbp:contains |
gptkb:indole_ring
nitrogen atom lysergic acid structure |
| gptkbp:discoveredBy |
gptkb:Friedrich_Sertürner
|
| gptkbp:discoveredIn |
19th century
|
| gptkbp:drugClass |
serotonin receptor agonist
adrenergic receptor agonist dopamine receptor agonist |
| gptkbp:effect |
physiological effect on humans
|
| gptkbp:etymology |
from Arabic al-qali
from Greek eidos (form) from Latin alkali |
| gptkbp:example |
gptkb:codeine
gptkb:morphine gptkb:ergocornine gptkb:ergocristine gptkb:ergocryptine gptkb:reserpine gptkb:ergometrine gptkb:ergotamine gptkb:lysergic_acid gptkb:strychnine gptkb:ergonovine caffeine quinine atropine nicotine colchicine theobromine |
| gptkbp:firstIsolatedFrom |
early 19th century
|
| gptkbp:foundIn |
gptkb:Claviceps_purpurea
gptkb:ergot_fungus animals fungi plants |
| gptkbp:hasMolecularFormula |
varies
C19H23N3O2 (ergotamine example) |
| gptkbp:hasProperty |
bitter taste
basic |
| gptkbp:hasRole |
defense mechanism in plants
|
| gptkbp:medicalUse |
migraine therapy
postpartum bleeding control |
| gptkbp:regulates |
gptkb:FDA
|
| gptkbp:relatedTo |
LSD
|
| gptkbp:sideEffect |
nausea
vomiting hypertension hallucinations gangrene vasospasm |
| gptkbp:structure |
usually contains at least one ring
|
| gptkbp:subclassOf |
gptkb:indole_alkaloids
gptkb:isoquinoline_alkaloids gptkb:pyridine_alkaloids pyrrolizidine alkaloids tropane alkaloids purine alkaloids quinolizidine alkaloids steroidal alkaloids terpenoid alkaloids ergoline alkaloid |
| gptkbp:toxicity |
high
can be toxic |
| gptkbp:usedAs |
gptkb:drug
vasoconstrictor recreational drug migraine treatment medicinal compound |
| gptkbp:usedHistoricallyFor |
inducing labor
controlling postpartum hemorrhage |
| gptkbp:usedIn |
neurology
obstetrics pesticides pharmaceuticals antihypertensives stimulants antimalarials muscle relaxants analgesics |
| gptkbp:bfsParent |
gptkb:capsaicin
gptkb:muscarine gptkb:Capsaicin gptkb:Piperine |
| gptkbp:bfsLayer |
5
|