|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:ATP
caffeine
calcium ions
low concentrations of ryanodine
|
|
gptkbp:associatedWith
|
gptkb:central_core_disease
gptkb:arrhythmogenic_right_ventricular_dysplasia
malignant hyperthermia
|
|
gptkbp:discoveredBy
|
gptkb:Andrew_Marks
|
|
gptkbp:domain
|
transmembrane domain
cytoplasmic domain
|
|
gptkbp:encodedBy
|
gptkb:RYR1_gene
gptkb:RYR2_gene
gptkb:RYR3_gene
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
cardiac muscle
|
|
gptkbp:foundIn
|
gptkb:endoplasmic_reticulum
sarcoplasmic reticulum
|
|
gptkbp:function
|
calcium release channel
|
|
gptkbp:gene
|
gptkb:RYR1
gptkb:RYR2
gptkb:RYR3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ryanodine receptor
|
|
gptkbp:inhibitedBy
|
gptkb:dantrolene
high concentrations of ryanodine
|
|
gptkbp:modulatedBy
|
gptkb:calmodulin
magnesium ions
|
|
gptkbp:molecularWeight
|
~2.2 MDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:central_core_disease
gptkb:catecholaminergic_polymorphic_ventricular_tachycardia
malignant hyperthermia susceptibility
|
|
gptkbp:namedAfter
|
ryanodine
|
|
gptkbp:OMIM
|
180901
|
|
gptkbp:orthologIn
|
inositol trisphosphate receptor
|
|
gptkbp:PDB
|
gptkb:5TAL
gptkb:5TAP
gptkb:5T15
|
|
gptkbp:regulates
|
intracellular calcium concentration
|
|
gptkbp:role
|
excitation-contraction coupling
calcium-induced calcium release
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subspecies
|
gptkb:RyR2
RyR1
RyR3
|
|
gptkbp:UniProtID
|
gptkb:Q92736
P21817
Q15413
|
|
gptkbp:bfsParent
|
gptkb:calmodulin
gptkb:FKBP12
|
|
gptkbp:bfsLayer
|
7
|