|
gptkbp:instanceOf
|
gptkb:protein
intracellular calcium channel
|
|
gptkbp:activatedBy
|
gptkb:inositol_1,4,5-trisphosphate_(IP3)
|
|
gptkbp:alternativeName
|
IP3R
ITPR
inositol 1,4,5-trisphosphate receptor
|
|
gptkbp:associatedWith
|
neurodegenerative diseases
spinocerebellar ataxia type 15
|
|
gptkbp:binds
|
gptkb:calcium_ion
gptkb:inositol_trisphosphate
|
|
gptkbp:discoveredBy
|
Clive W. Taylor
|
|
gptkbp:encodedBy
|
ITPR1 gene
ITPR2 gene
ITPR3 gene
|
|
gptkbp:firstDescribed
|
1985
|
|
gptkbp:foundIn
|
animals
invertebrates
vertebrates
|
|
gptkbp:function
|
mediates release of calcium ions from endoplasmic reticulum
|
|
gptkbp:hasIsoform
|
IP3R1
IP3R2
IP3R3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IP3 receptor
|
|
gptkbp:involvedIn
|
calcium signaling pathway
cellular signal transduction
|
|
gptkbp:locatedIn
|
endoplasmic reticulum membrane
|
|
gptkbp:modulatedBy
|
gptkb:ATP
gptkb:calmodulin
gptkb:protein_kinase_C
gptkb:protein_kinase_A
phosphorylation
|
|
gptkbp:PDB
|
gptkb:5TAP
3UJ0
6DQJ
|
|
gptkbp:regulates
|
cytosolic calcium concentration
|
|
gptkbp:relatedTo
|
gptkb:ryanodine_receptor
|
|
gptkbp:requires
|
gptkb:synaptic_plasticity
apoptosis
cell proliferation
muscle contraction
learning and memory
fertilization
neuronal signaling
metabolic regulation
hormone secretion
immune cell activation
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subunit
|
gptkb:calcium_release_complex
|
|
gptkbp:bfsParent
|
gptkb:IP3
gptkb:inositol_trisphosphate_(IP3)
gptkb:inositol_1,4,5-trisphosphate_(IP3)
gptkb:inositol_1,4,5-trisphosphate
|
|
gptkbp:bfsLayer
|
7
|