Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:drug |
| gptkbp:administeredBy |
intravenous injection
|
| gptkbp:antidote |
gptkb:tranexamic_acid
aminocaproic acid |
| gptkbp:approvalYear |
1996
|
| gptkbp:approvedBy |
gptkb:FDA
|
| gptkbp:ATCCode |
B01AD02
|
| gptkbp:brand |
gptkb:Alteplase
|
| gptkbp:CASNumber |
105857-23-6
|
| gptkbp:category |
gptkb:tissue_plasminogen_activator
gptkb:enzyme fibrinolytic drug |
| gptkbp:contraindication |
active internal bleeding
severe uncontrolled hypertension history of hemorrhagic stroke recent major surgery |
| gptkbp:eliminatedIn |
hepatic
|
| gptkbp:form |
solution for injection
lyophilized powder |
| gptkbp:foundIn |
human body
|
| gptkbp:fullName |
recombinant tissue plasminogen activator
|
| gptkbp:gene |
gptkb:PLAT
|
| gptkbp:halfLife |
4-6 minutes
|
| https://www.w3.org/2000/01/rdf-schema#label |
rtPA
|
| gptkbp:indication |
massive pulmonary embolism
acute ischemic stroke within 3-4.5 hours of onset ST-elevation myocardial infarction (STEMI) |
| gptkbp:marketedAs |
gptkb:Boehringer_Ingelheim
gptkb:Genentech |
| gptkbp:mechanismOfAction |
converts plasminogen to plasmin
dissolves blood clots |
| gptkbp:molecularWeight |
~70 kDa
|
| gptkbp:notRecommendedFor |
hemorrhagic stroke
minor stroke recent head trauma |
| gptkbp:orthologIn |
tPA (tissue plasminogen activator)
|
| gptkbp:producedBy |
liver
genetic engineering |
| gptkbp:riskFactor |
allergic reaction
angioedema major bleeding |
| gptkbp:sideEffect |
bleeding
intracranial hemorrhage |
| gptkbp:storage |
refrigerated
|
| gptkbp:structureType |
gptkb:protein
|
| gptkbp:UNII |
6Z5B6HVF6O
|
| gptkbp:usedFor |
myocardial infarction
pulmonary embolism acute ischemic stroke |
| gptkbp:bfsParent |
gptkb:alteplase
|
| gptkbp:bfsLayer |
7
|