protein tyrosine phosphatase, non-receptor type 22
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:alternativeName |
gptkb:PTPN22
gptkb:Lyp |
| gptkbp:associatedWith |
gptkb:systemic_lupus_erythematosus
type 1 diabetes autoimmune diseases rheumatoid arthritis |
| gptkbp:biologicalProcess |
protein tyrosine phosphatase activity
|
| gptkbp:encodedBy |
PTPN22 gene
|
| gptkbp:expressedIn |
immune cells
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
regulation of T-cell receptor signaling
dephosphorylation of phosphotyrosine residues |
| https://www.w3.org/2000/01/rdf-schema#label |
protein tyrosine phosphatase, non-receptor type 22
|
| gptkbp:locatedOnChromosome |
1p13.2
|
| gptkbp:mutationAssociatedWith |
R620W variant
|
| gptkbp:R620W_variant |
increases risk of autoimmunity
|
| gptkbp:regulates |
T-cell activation
B-cell signaling |
| gptkbp:UniProtID |
gptkb:Q9Y2R2
|
| gptkbp:bfsParent |
gptkb:PTPN22
|
| gptkbp:bfsLayer |
7
|