precursor B-cell acute lymphoblastic leukemia
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
leukemia acute lymphoblastic leukemia subtype |
| gptkbp:affects |
blood
bone marrow |
| gptkbp:hasCellOfOrigin |
B-cell precursor
|
| gptkbp:hasDiagnosticMethod |
bone marrow biopsy
cytogenetic analysis immunophenotyping flow cytometry |
| gptkbp:hasGeneticAlteration |
hyperdiploidy
MLL rearrangement t(12;21)(p13;q22) ETV6-RUNX1 t(9;22)(q34;q11) BCR-ABL1 |
| gptkbp:hasMaintenanceTherapy |
gptkb:methotrexate
gptkb:vincristine 6-mercaptopurine corticosteroids |
| gptkbp:hasPeakIncidence |
children aged 2-5 years
|
| gptkbp:hasRelapseRisk |
higher in adults
lower in children |
| gptkbp:hasRemissionRate |
lower in adults
over 90% in children |
| https://www.w3.org/2000/01/rdf-schema#label |
precursor B-cell acute lymphoblastic leukemia
|
| gptkbp:ICD-10_code |
gptkb:C91.0
|
| gptkbp:prevalence |
most common childhood cancer
|
| gptkbp:prognosis |
variable
generally favorable in children less favorable in adults |
| gptkbp:riskFactor |
gptkb:Down_syndrome
radiation exposure genetic predisposition previous chemotherapy |
| gptkbp:subspecies |
leukemia
|
| gptkbp:symptom |
fever
fatigue bone pain easy bruising frequent infections pallor |
| gptkbp:synonym |
gptkb:B-cell_ALL
B-precursor ALL |
| gptkbp:treatment |
chemotherapy
immunotherapy stem cell transplantation hematologist pediatric oncologist targeted therapy |
| gptkbp:bfsParent |
gptkb:pre-B-cell_acute_lymphoblastic_leukemia
|
| gptkbp:bfsLayer |
7
|