paclitaxel molecule

URI: https://gptkb.org/entity/paclitaxel_molecule

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound antineoplastic agent
gptkbp:approvedBy	1992 (US FDA)
gptkbp:ATCCode	L01CD01
gptkbp:biosynthesized_from	plant secondary metabolism
gptkbp:brand	gptkb:Abraxane gptkb:Taxol Onxol
gptkbp:CASNumber	33069-62-4
gptkbp:chemicalFormula	C47H51NO14
gptkbp:discoveredBy	gptkb:Mansukh_C._Wani gptkb:Monroe_E._Wall
gptkbp:discoveredIn	1971
gptkbp:eliminationHalfLife	5.8 to 24 hours
gptkbp:excretion	urine bile
gptkbp:foundIn	gptkb:Pacific_yew_tree
https://www.w3.org/2000/01/rdf-schema#label	paclitaxel molecule
gptkbp:inhibitedBy	mitosis
gptkbp:IUPACName	(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-11-acetoxy-12-(benzoyloxy)-1,2a,6,9,12,12a-hexahydroxy-4,8,13,13-tetramethyl-5-oxo-5,4a,6,9,11,12,12b,13-octahydro-4H,6H,12H-oxeto[2,3-d][1]benzopyran-4-yl benzoate
gptkbp:KEGGID	D05367
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	stabilizes microtubules
gptkbp:meltingPoint	216-217 °C
gptkbp:metabolism	liver
gptkbp:molecularWeight	853.9 g/mol
gptkbp:origin	natural product
gptkbp:pregnancyCategory	D (US)
gptkbp:producedBy	gptkb:lake gptkb:Taxus_brevifolia
gptkbp:PubChem_CID	gptkb:CHEMBL92 36314 DB01229 CHEBI:45863
gptkbp:routeOfAdministration	intravenous
gptkbp:sideEffect	nausea vomiting hair loss peripheral neuropathy neutropenia
gptkbp:solubility	insoluble
gptkbp:structureType	taxane diterpenoid
gptkbp:target	tubulin
gptkbp:toxicity	myelosuppression hypersensitivity reactions
gptkbp:UNII	P88XT4IS4D
gptkbp:usedFor	gptkb:cancer gptkb:Kaposi's_sarcoma
gptkbp:bfsParent	gptkb:E_ring
gptkbp:bfsLayer	7