Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
gptkb:OPN
secreted phosphoprotein 1 |
| gptkbp:binds |
gptkb:integrins
gptkb:CD44 |
| gptkbp:discoveredIn |
1986
|
| gptkbp:encodedBy |
SPP1 gene
|
| gptkbp:foundIn |
humans
mice other mammals |
| gptkbp:function |
wound healing
inflammation cell adhesion immune response regulation bone remodeling |
| https://www.w3.org/2000/01/rdf-schema#label |
osteopontin
|
| gptkbp:involvedIn |
gptkb:bone
atherosclerosis autoimmune diseases cancer progression fibrosis |
| gptkbp:locatedOnChromosome |
human chromosome 4q22.1
|
| gptkbp:location |
gptkb:bone
gptkb:kidney extracellular matrix immune cells |
| gptkbp:molecularWeight |
~44 kDa
|
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation |
| gptkbp:role |
gptkb:Th1_immune_response
angiogenesis cell migration T cell activation tumor metastasis chronic inflammation tissue repair bone mineralization calcification inhibition macrophage chemotaxis renal stone formation wound contraction |
| gptkbp:secretes |
macrophages
activated T cells osteoblasts |
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:structure |
intrinsically disordered protein
|
| gptkbp:UniProtID |
P10451
|
| gptkbp:bfsParent |
gptkb:CD44
gptkb:SPP1 |
| gptkbp:bfsLayer |
7
|