Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
antineoplastic agent class of cytotoxic chemotherapy drugs |
| gptkbp:administeredBy |
intravenous injection
oral administration |
| gptkbp:category |
antineoplastic agents
DNA-damaging agents vesicants |
| gptkbp:contains_functional_group |
bis(2-chloroethyl)amine
|
| gptkbp:derivedFrom |
mustard gas
|
| gptkbp:discoveredIn |
1940s
|
| gptkbp:example |
gptkb:cyclophosphamide
gptkb:chlorambucil gptkb:melphalan gptkb:ifosfamide gptkb:mechlorethamine |
| https://www.w3.org/2000/01/rdf-schema#label |
nitrogen mustards
|
| gptkbp:mechanismOfAction |
alkylation of DNA
|
| gptkbp:regulates |
gptkb:FDA
gptkb:EMA |
| gptkbp:relatedTo |
sulfur mustards
|
| gptkbp:toxicity |
nausea
vomiting immunosuppression bone marrow suppression secondary malignancies |
| gptkbp:usedFor |
immunosuppression
cancer chemotherapy |
| gptkbp:usedIn |
breast cancer treatment
Hodgkin lymphoma treatment multiple myeloma treatment non-Hodgkin lymphoma treatment ovarian cancer treatment |
| gptkbp:bfsParent |
gptkb:nitrogen_mustard
|
| gptkbp:bfsLayer |
7
|