muscarinic acetylcholine receptor M4

URI: https://gptkb.org/entity/muscarinic_acetylcholine_receptor_M4
GPTKB entity
Statements (40)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:G_protein-coupled_receptor
gptkbp:alternativeName gptkb:CHRM4
M4 muscarinic receptor
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
schizophrenia
gptkbp:encodedBy CHRM4 gene
gptkbp:enemyOf gptkb:muscarine
atropine
gptkbp:Entrez_Gene_ID 1132
gptkbp:expressedIn brain
central nervous system
gptkbp:family muscarinic acetylcholine receptor family
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function inhibits adenylate cyclase activity
mediates acetylcholine signaling
https://www.w3.org/2000/01/rdf-schema#label muscarinic acetylcholine receptor M4
gptkbp:involvedIn cognitive processes
modulation of dopamine release
regulation of locomotor activity
gptkbp:length 479 amino acids
gptkbp:ligand gptkb:acetylcholine
gptkbp:locatedOnChromosome 11q12-q13
gptkbp:location gptkb:cell_membrane
gptkbp:molecularWeight 53 kDa
gptkbp:OMIM 118495
gptkbp:PDB 5DSG
gptkbp:pharmgkbID PA30938
gptkbp:RefSeq NP_000734.1
gptkbp:relatedTo gptkb:muscarinic_acetylcholine_receptor_M1
muscarinic acetylcholine receptor M2
muscarinic acetylcholine receptor M3
muscarinic acetylcholine receptor M5
gptkbp:structure 7 transmembrane domains
gptkbp:type Gi/o protein
gptkbp:UniProtID P08173
gptkbp:bfsParent gptkb:xanomeline
gptkb:CHRM4
gptkbp:bfsLayer 7