|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
Nanog homeobox
Homeobox protein Nanog
|
|
gptkbp:discoveredBy
|
gptkb:Austin_Smith
|
|
gptkbp:downregulated_during
|
differentiation
|
|
gptkbp:encodes
|
Nanog protein
|
|
gptkbp:Entrez_Gene_ID
|
ENSMUSG00000020682
|
|
gptkbp:expressedIn
|
embryonic stem cells
|
|
gptkbp:expression_marker_for
|
pluripotent stem cells
|
|
gptkbp:firstDescribed
|
2003
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:GO_function
|
DNA-binding transcription factor activity
|
|
gptkbp:GOProcess
|
cell differentiation
regulation of transcription, DNA-templated
stem cell population maintenance
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse Nanog
|
|
gptkbp:inhibitedBy
|
differentiation into extraembryonic endoderm
differentiation into trophectoderm
|
|
gptkbp:interactsWith
|
gptkb:Tcf3
Dax1
Esrrb
Nac1
Oct4 protein
Sall4
Sox2 protein
Zfp281
|
|
gptkbp:length
|
305
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6
|
|
gptkbp:MGI_ID
|
MGI:2449038
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
human NANOG
|
|
gptkbp:proteinFamily
|
homeodomain
|
|
gptkbp:regulates
|
gptkb:Rex1
gptkb:Klf4
gptkb:Sox2
gptkb:Oct4
cell fate decisions
Tbx3
Esrrb
|
|
gptkbp:requires
|
ground state pluripotency
|
|
gptkbp:role
|
maintenance of pluripotency
self-renewal of embryonic stem cells
|
|
gptkbp:sequence_accession
|
NM_028016
|
|
gptkbp:transcriptional_target_of
|
gptkb:Sox2
gptkb:Oct4
|
|
gptkbp:UniProtID
|
Q80Z64
|
|
gptkbp:upregulated_by
|
LIF/Stat3 signaling
|
|
gptkbp:used_in
|
induced pluripotent stem cell generation
|
|
gptkbp:bfsParent
|
gptkb:Nanog
|
|
gptkbp:bfsLayer
|
7
|