|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:cannabinoid_receptor_type_1
gptkb:CB1
|
|
gptkbp:biologicalProcess
|
cannabinoid receptor activity
G-protein coupled receptor activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
axon terminal
neuronal cell body
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodes
|
gptkb:cannabinoid_receptor_1
|
|
gptkbp:enemyOf
|
gptkb:WIN_55,212-2
gptkb:SR141716A
gptkb:rimonabant
Δ9-tetrahydrocannabinol (THC)
|
|
gptkbp:Entrez_Gene_ID
|
12809
ENSMUSG00000045345
|
|
gptkbp:expressedIn
|
central nervous system
peripheral tissues
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
mediates effects of endocannabinoids
|
|
gptkbp:gene
|
gptkb:Cnr1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse Cnr1
|
|
gptkbp:length
|
472 amino acids
|
|
gptkbp:ligand
|
gptkb:anandamide
gptkb:2-arachidonoylglycerol_(2-AG)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
|
|
gptkbp:MGI_ID
|
MGI:88590
|
|
gptkbp:mutationAssociatedWith
|
impaired memory
altered pain sensitivity
altered appetite
altered motor activity
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
human CNR1
|
|
gptkbp:pathway
|
gptkb:endocannabinoid_signaling_pathway
gptkb:retrograde_endocannabinoid_signaling
|
|
gptkbp:product
|
gptkb:CB1_receptor
|
|
gptkbp:related_disease_model
|
addiction
epilepsy
obesity
anxiety
|
|
gptkbp:relatedTo
|
memory
synaptic transmission
motor control
neuromodulation
appetite regulation
pain perception
|
|
gptkbp:bfsParent
|
gptkb:cannabinoid_receptor_type_1
|
|
gptkbp:bfsLayer
|
8
|