mitochondrial respiratory chain complex IV

URI: https://gptkb.org/entity/mitochondrial_respiratory_chain_complex_IV
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs cytochrome c oxidase
gptkbp:cofactor gptkb:heme_a3
gptkb:heme_a
copper centers
gptkbp:component electron transport chain
gptkbp:discoveredBy gptkb:David_Keilin
gptkbp:discoveredIn 1920s
gptkbp:EC_number 1.9.3.1
gptkbp:encodedBy gptkb:mitochondrial_DNA
nuclear DNA
gptkbp:function catalyzes the reduction of oxygen to water
pumps protons across the mitochondrial membrane
transfers electrons from cytochrome c to oxygen
gptkbp:GO_term gptkb:GO:0005751
https://www.w3.org/2000/01/rdf-schema#label mitochondrial respiratory chain complex IV
gptkbp:inhibitedBy carbon monoxide
azide
cyanide
gptkbp:locatedIn inner mitochondrial membrane
gptkbp:molecularWeight ~200 kDa
gptkbp:mutationAssociatedWith mitochondrial diseases
gptkbp:numberOfSubunits 13 (in humans)
gptkbp:OMIM 220110
gptkbp:presentIn eukaryotes
gptkbp:requires aerobic respiration
gptkbp:role oxidative phosphorylation
gptkbp:subunit gptkb:COX1
gptkb:COX2
gptkb:COX3
gptkbp:UniProtID P00396 (for human COX1 subunit)
gptkbp:bfsParent gptkb:MT-CO1
gptkbp:bfsLayer 7