methyl CpG binding protein 2

URI: https://gptkb.org/entity/methyl_CpG_binding_protein_2
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:MECP2
gptkbp:alternativeSplicing produces multiple isoforms
gptkbp:associatedWith gptkb:autism_spectrum_disorder
gptkb:Rett_syndrome
X-linked mental retardation
gptkbp:discoveredBy gptkb:Adrian_Bird
gptkbp:discoveredIn 1992
gptkbp:domain gptkb:MBD_(methyl-CpG-binding_domain)
transcriptional repression domain
gptkbp:encodedBy gptkb:MECP2_gene
gptkbp:Entrez_Gene_ID 4204
gptkbp:expressedIn gptkb:nervous_system
brain
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function transcriptional repression
binds methylated DNA
https://www.w3.org/2000/01/rdf-schema#label methyl CpG binding protein 2
gptkbp:interactsWith gptkb:SIN3A
gptkb:HDAC1
gptkb:CREB1
gptkbp:locatedOnChromosome gptkb:Xq28
gptkbp:molecularWeight 53 kDa
gptkbp:mutationAssociatedWith causes neurodevelopmental disorders
gptkbp:OMIM 300005
gptkbp:orthologIn gptkb:Mus_musculus
gptkbp:PDB 1QK9
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:regulates gene expression
gptkbp:UniProtID gptkb:P51608
gptkbp:bfsParent gptkb:MECP2
gptkbp:bfsLayer 7