ezetimibe

GPTKB entity

Statements (55)
Predicate Object
gptkbp:instanceOf gptkb:drug
cholesterol absorption inhibitor
gptkbp:approvalYear 2002
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode gptkb:C10AX09
gptkbp:bioavailability unknown
gptkbp:brand gptkb:Ezetrol
gptkb:Zetia
gptkbp:CASNumber gptkb:163222-33-1
gptkbp:chemicalClass beta-lactam
gptkbp:combinationProduct gptkb:Liptruzet
gptkb:Vytorin
gptkbp:combines gptkb:atorvastatin
gptkb:simvastatin
gptkbp:contraindication active liver disease
gptkbp:cost generic available
gptkbp:developedBy gptkb:Schering-Plough
gptkbp:discoveredBy gptkb:Bruce_D._Roth
gptkbp:effect lowers LDL cholesterol
reduces total cholesterol
gptkbp:eliminationHalfLife 22 hours
gptkbp:excretion urine
feces
gptkbp:hasMolecularFormula C24H21F2NO3
https://www.w3.org/2000/01/rdf-schema#label ezetimibe
gptkbp:KEGGID D04022
gptkbp:legalStatus prescription only
gptkbp:liverMetabolism glucuronidation
gptkbp:marketedAs 2002
gptkbp:mechanismOfAction inhibits NPC1L1 protein
gptkbp:MedlinePlusID a603015
gptkbp:MeSH_ID D000068879
gptkbp:metabolism liver
gptkbp:patent 1996
gptkbp:pregnancyCategory C (US)
B3 (Australia)
not recommended in pregnancy
gptkbp:proteinBinding 99%
gptkbp:PubChem_CID gptkb:CHEMBL1201197
150311
DB00973
gptkbp:routeOfAdministration oral
gptkbp:sideEffect diarrhea
abdominal pain
fatigue
elevated liver enzymes
gptkbp:synonym gptkb:Ezetimiba
gptkb:Ezetimibum
gptkb:SCH_58235
gptkbp:UNII A256257SYN
gptkbp:usedFor gptkb:familial_hypercholesterolemia
gptkb:sitosterolemia
gptkbp:bfsParent gptkb:Vytorin
gptkb:Zetia
gptkbp:bfsLayer 5