desmopressin

URI: https://gptkb.org/entity/desmopressin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:drug
gptkbp:approvalYear	1978
gptkbp:ATCCode	gptkb:H01BA02
gptkbp:brand	gptkb:Minirin gptkb:DDAVP gptkb:Stimate
gptkbp:CASNumber	16679-58-6
gptkbp:chemicalFormula	C46H64N14O12S2
gptkbp:contraindication	hyponatremia polydipsia moderate to severe renal impairment
gptkbp:developedBy	gptkb:vasopressin
gptkbp:discoveredBy	gptkb:Novo_Nordisk
gptkbp:eliminationHalfLife	2–3 hours
gptkbp:excretion	renal
https://www.w3.org/2000/01/rdf-schema#label	desmopressin
gptkbp:isPeptide	true
gptkbp:IUPACName	(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(1-carbamoylethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	vasopressin receptor agonist
gptkbp:metabolism	hepatic
gptkbp:molecularWeight	1069.22 g/mol
gptkbp:pregnancyCategory	B (US) B2 (Australia)
gptkbp:proteinBinding	40–50%
gptkbp:routeOfAdministration	oral intravenous intranasal sublingual
gptkbp:sideEffect	nausea abdominal pain headache hyponatremia
gptkbp:UNII	Q528IWT3HI
gptkbp:usedFor	gptkb:von_Willebrand_disease gptkb:hemophilia_A gptkb:diabetes_insipidus bedwetting
gptkbp:bfsParent	gptkb:von_Willebrand's_disease gptkb:Imodium
gptkbp:bfsLayer	5