|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:abusePotential
|
low
|
|
gptkbp:approvalYear
|
1976
|
|
gptkbp:ATCCode
|
A07DA03
|
|
gptkbp:availableOn
|
many countries worldwide
|
|
gptkbp:brand
|
gptkb:Johnson_&_Johnson
|
|
gptkbp:CASNumber
|
53179-11-6
|
|
gptkbp:chemicalFormula
|
C29H33ClN2O2
|
|
gptkbp:contraindication
|
children under 2 years
bacterial enterocolitis
bloody diarrhea
|
|
gptkbp:drugClass
|
antidiarrheal
|
|
gptkbp:eliminationHalfLife
|
9-14 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:form
|
gptkb:tablet
capsule
oral solution
|
|
gptkbp:genericName
|
gptkb:loperamide
|
|
gptkbp:hasBoxedWarning
|
serious cardiac adverse reactions with high doses
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Imodium
|
|
gptkbp:interactsWith
|
gptkb:desmopressin
gptkb:ritonavir
gptkb:gemfibrozil
gptkb:erythromycin
gptkb:ketoconazole
gptkb:verapamil
cimetidine
quinidine
|
|
gptkbp:legalStatus
|
gptkb:OTC
Rx-only
|
|
gptkbp:manufacturer
|
gptkb:Johnson_&_Johnson
|
|
gptkbp:mechanismOfAction
|
mu-opioid receptor agonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notRecommendedFor
|
children under 2 years
patients with acute dysentery
patients with ulcerative colitis
|
|
gptkbp:overdoseSymptoms
|
gptkb:arrhythmia
CNS depression
|
|
gptkbp:pregnancyCategory
|
C (US)
B2 (Australia)
|
|
gptkbp:prescriptionRequired
|
varies by country
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
abdominal pain
constipation
drowsiness
|
|
gptkbp:usedFor
|
diarrhea
|
|
gptkbp:bfsParent
|
gptkb:Johnson_&_Johnson
|
|
gptkbp:bfsLayer
|
4
|