Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cytokine |
| gptkbp:composedOf |
IL-12A (p35) subunit
IL-12B (p40) subunit |
| gptkbp:discoveredIn |
1989
|
| gptkbp:function |
stimulates differentiation of naive T cells into Th1 cells
enhances cytotoxic activity of natural killer (NK) cells induces production of interferon-gamma (IFN-γ) promotes cell-mediated immunity |
| gptkbp:gene |
gptkb:IL12A
gptkb:IL12B |
| gptkbp:HGNC_ID |
HGNC:5977 (IL12A)
HGNC:5978 (IL12B) |
| https://www.w3.org/2000/01/rdf-schema#label |
interleukin-12 (IL-12)
|
| gptkbp:involvedIn |
autoimmune diseases
inflammation immune response |
| gptkbp:locatedOnChromosome |
IL12A: chromosome 3
IL12B: chromosome 5 |
| gptkbp:MeSH_ID |
D016207
|
| gptkbp:producedBy |
gptkb:B_cells
dendritic cells macrophages |
| gptkbp:recipient |
gptkb:interleukin-12_receptor
|
| gptkbp:role |
tumor immunity
host defense against intracellular pathogens |
| gptkbp:structure |
heterodimer
|
| gptkbp:symbol |
gptkb:IL-12
|
| gptkbp:target |
gptkb:ustekinumab
therapeutic antibodies |
| gptkbp:UniProtID |
gptkb:P29459_(IL12A)
gptkb:P29460_(IL12B) |
| gptkbp:bfsParent |
gptkb:NKp44
|
| gptkbp:bfsLayer |
8
|