Chronic Granulomatous Disease

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:immunodeficiency gptkb:rare_disease
gptkbp:abbreviation	gptkb:CGD
gptkbp:affects	adults children phagocytes
gptkbp:category	gptkb:genetic_disorder gptkb:immune_system_disorder
gptkbp:cause	recurrent infections granuloma formation
gptkbp:causedBy	gptkb:genetic_disorder
gptkbp:characterizedBy	defective NADPH oxidase
gptkbp:complication	gptkb:inflammatory_bowel_disease autoimmune disorders liver abscess lung granulomas
gptkbp:diagnosedBy	gptkb:dihydrorhodamine_(DHR)_test gptkb:nitroblue_tetrazolium_(NBT)_test
gptkbp:firstDescribed	1957
gptkbp:inheritance	autosomal recessive X-linked
gptkbp:involvedIn	gptkb:CYBA gptkb:NCF1 gptkb:NCF2 gptkb:NCF4 gptkb:CYBB
gptkbp:MeSH_ID	D006061
gptkbp:mostCommonInheritance	X-linked recessive
gptkbp:namedFor	gptkb:Robert_A._Good
gptkbp:OMIM	306400
gptkbp:otherInheritance	autosomal recessive
gptkbp:prevalence	1 in 200,000 to 250,000 live births
gptkbp:riskFactor	gptkb:Aspergillus_infection gptkb:Burkholderia_cepacia_infection gptkb:Serratia_marcescens_infection gptkb:Staphylococcus_aureus_infection Nocardia infection
gptkbp:symptom	gptkb:pneumonia skin infections osteomyelitis lymphadenitis abscesses
gptkbp:treatment	gptkb:interferon_gamma hematopoietic stem cell transplantation antibiotic prophylaxis antifungal prophylaxis
gptkbp:bfsParent	gptkb:CGD
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Chronic Granulomatous Disease