chronic graft versus host disease
GPTKB entity
Statements (45)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
|
| gptkbp:abbreviation |
cGVHD
|
| gptkbp:affects |
gptkb:skin
lungs gastrointestinal tract liver eyes mouth musculoskeletal system patients after allogeneic hematopoietic stem cell transplantation |
| gptkbp:cause |
chronic pain
increased risk of infection organ failure functional impairment secondary malignancies immune reaction of donor cells against host tissues |
| gptkbp:complication |
gptkb:allogeneic_stem_cell_transplantation
|
| gptkbp:diagnosedBy |
clinical criteria
biopsy |
| gptkbp:firstDescribed |
1970s
|
| https://www.w3.org/2000/01/rdf-schema#label |
chronic graft versus host disease
|
| gptkbp:ICD-10_code |
T86.0
|
| gptkbp:managedBy |
multidisciplinary care
|
| gptkbp:MeSH_ID |
gptkb:D005778
|
| gptkbp:mortalityRate |
10-30% (varies by severity and organ involvement)
|
| gptkbp:prevalence |
30-70% of allogeneic transplant recipients
|
| gptkbp:relatedTo |
gptkb:acute_graft_versus_host_disease
|
| gptkbp:researchInterest |
biomarker discovery
novel therapies improving immunosuppression |
| gptkbp:riskFactor |
gptkb:HLA_mismatch
older age of donor or recipient previous acute GVHD |
| gptkbp:symptom |
skin rash
joint stiffness dry mouth liver dysfunction dry eyes lung involvement |
| gptkbp:treatment |
corticosteroids
immunosuppressive drugs extracorporeal photopheresis |
| gptkbp:bfsParent |
gptkb:Imbruvica
gptkb:ibrutinib |
| gptkbp:bfsLayer |
7
|