DB09053

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:antidote gptkb:idarucizumab
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode B01AE07
gptkbp:bioavailability 6.5%
gptkbp:blackBoxWarning increased risk of thrombotic events after premature discontinuation
risk of spinal/epidural hematoma
gptkbp:brand gptkb:Pradaxa
gptkbp:CASNumber 211915-06-9
gptkbp:contraindication active pathological bleeding
mechanical prosthetic heart valves
gptkbp:drugClass gptkb:anticoagulant
antithrombotic agent
gptkbp:eliminatedIn urine
gptkbp:eliminationHalfLife 12-17 hours
gptkbp:excretion renal
gptkbp:hasCYPInteraction not a CYP substrate
gptkbp:hasInChIKey QBPWTZUNXWNLGA-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C34H41N7O5
gptkbp:hasReversalAgent gptkb:idarucizumab
gptkbp:hasSMILES CC(C)N1C(=O)NC(C(=O)N(C2CC2)C3=CC=CC=C3)C1=O
gptkbp:hasUNII 2ZC1894524
https://www.w3.org/2000/01/rdf-schema#label DB09053
gptkbp:indication treatment and prevention of deep vein thrombosis
treatment and prevention of pulmonary embolism
prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation
gptkbp:legalStatus prescription only
patented
gptkbp:manufacturer gptkb:Boehringer_Ingelheim
gptkbp:mechanismOfAction direct thrombin inhibitor
gptkbp:metabolism liver
gptkbp:molecularWeight 627.74
gptkbp:name gptkb:Dabigatran
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 35%
gptkbp:PubChem_CID gptkb:DB09053
148124
D08167
CHEMBL1219
gptkbp:routeOfAdministration oral
gptkbp:sideEffect bleeding
gastrointestinal upset
gptkbp:synonym gptkb:BIBR_1048
gptkb:Dabigatran_etexilate
gptkbp:target gptkb:thrombin_(F2)
gptkbp:bfsParent gptkb:ibrutinib
gptkbp:bfsLayer 7