human hemoglobin subunit beta

URI: https://gptkb.org/entity/human_hemoglobin_subunit_beta
GPTKB entity
Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:HBB_protein
beta-globin
gptkbp:clinical_test hemoglobin electrophoresis
gptkbp:component hemoglobin
gptkbp:contains heme group
gptkbp:disease_involvement hemoglobinopathies
gptkbp:encodedBy gptkb:HBB_gene
gptkbp:Entrez_Gene_ID gptkb:HBB
gptkb:ENSP00000335295
gptkbp:expressed_during adult stage
gptkbp:expressedIn bone marrow
gptkbp:firstDescribed 1950s
gptkbp:formsComplexWith gptkb:hemoglobin_subunit_alpha
gptkbp:foundIn hemoglobin
gptkbp:function oxygen transport
gptkbp:GO_component gptkb:hemoglobin_complex
gptkbp:GO_function oxygen transporter activity
gptkbp:GOProcess oxygen transport
gptkbp:heldBy heme protein
gptkbp:HGNC_ID 4827
https://www.w3.org/2000/01/rdf-schema#label human hemoglobin subunit beta
gptkbp:interactsWith 2,3-bisphosphoglycerate (2,3-BPG)
gptkbp:locatedOnChromosome 11p15.4
gptkbp:molecularWeight 15.9 kDa
gptkbp:mutationAssociatedWith sickle cell disease
beta thalassemia
Glu26Lys (HbE mutation)
Glu6Lys (HbC mutation)
Glu6Val (sickle cell mutation)
various beta thalassemia mutations
gptkbp:not_expressed_during fetal stage
gptkbp:OMIM 141900
gptkbp:organism gptkb:Homo_sapiens
gptkbp:ortholog_in_chimpanzee gptkb:HBB
gptkbp:orthologInMouse gptkb:Hbb-b1
gptkbp:PDB 1A3N
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:proteinFamily globin family
gptkbp:RefSeq gptkb:NP_000509.1
gptkbp:replacedBy hemoglobin subunit gamma (in fetus)
gptkbp:sequence 147 amino acids
gptkbp:stable hydrogen bonds
salt bridges
gptkbp:structure globin fold
gptkbp:subunit hemoglobin A (HbA)
hemoglobin C (HbC)
hemoglobin E (HbE)
hemoglobin S (HbS)
gptkbp:UniProtID P68871
gptkbp:bfsParent gptkb:NP_000609.1
gptkbp:bfsLayer 8