histamine methyltransferase

URI: https://gptkb.org/entity/histamine_methyltransferase
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:HNMT
histamine N-methyltransferase
gptkbp:associatedWith allergic diseases
histamine metabolism
asthma susceptibility
allergic response regulation
gptkbp:biologicalProcess methyltransferase activity
histamine catabolic process
gptkbp:catalyzes methylation of histamine
gptkbp:cofactor gptkb:S-adenosyl-L-methionine
gptkbp:EC_number 2.1.1.8
gptkbp:foundIn gptkb:kidney
central nervous system
liver
cytosol
gptkbp:function inactivates histamine
gptkbp:gene gptkb:HNMT
https://www.w3.org/2000/01/rdf-schema#label histamine methyltransferase
gptkbp:inhibitedBy gptkb:metoprine
gptkb:quinacrine
gptkbp:length 292 amino acids
gptkbp:locatedOnChromosome 2q22.1
gptkbp:OMIM 601922
gptkbp:organism gptkb:Homo_sapiens
gptkbp:product gptkb:N-methylhistamine
gptkb:S-adenosyl-L-homocysteine
gptkbp:structure monomeric protein
gptkbp:substrate gptkb:histamine
gptkbp:UniProtID gptkb:P50135
gptkbp:bfsParent gptkb:histamine-N-methyltransferase
gptkbp:bfsLayer 8