|
gptkbp:instanceOf
|
gptkb:antiviral_drug
gptkb:dye
gptkb:chemical_compound
gptkb:antineoplastic_agent
|
|
gptkbp:ATCCode
|
P01BA02
|
|
gptkbp:brand
|
Atabrine
|
|
gptkbp:CASNumber
|
83-89-6
|
|
gptkbp:category
|
gptkb:dye
gptkb:antimalarial
gptkb:anthelmintic
antiprotozoal
DNA intercalator
acridine derivative
antirheumatic agent
|
|
gptkbp:chemicalFormula
|
C23H30ClN3O
|
|
gptkbp:color
|
yellow
|
|
gptkbp:discoveredBy
|
I.G. Farben
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:firstSynthesized
|
1931
|
|
gptkbp:IUPACName
|
N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylpentane-1,4-diamine
|
|
gptkbp:KEGGID
|
D08441
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
intercalates into DNA
inhibits phospholipase A2
|
|
gptkbp:meltingPoint
|
174–175 °C
|
|
gptkbp:MeSH_ID
|
D011789
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
399.96 g/mol
|
|
gptkbp:pKa
|
10.3
|
|
gptkbp:PubChem_CID
|
237
CHEMBL1536
DB01103
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
headache
psychosis
gastrointestinal upset
yellow discoloration of skin
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:UNII
|
D72O4R1U1B
|
|
gptkbp:used_in
|
gptkb:World_War_II
|
|
gptkbp:usedFor
|
treatment of malaria
treatment of giardiasis
non-surgical sterilization (off-label)
treatment of lupus erythematosus
treatment of tapeworm infection
|
|
gptkbp:bfsParent
|
gptkb:histamine-N-methyltransferase
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
quinacrine
|