|
gptkbp:instanceOf
|
gptkb:G_protein-coupled_receptor
antihistamine
|
|
gptkbp:alternativeName
|
gptkb:histamine_H3_receptor
gptkb:HRH3
|
|
gptkbp:couplingType
|
gptkb:Gi/o_proteins
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:effect
|
activates potassium channels
inhibits calcium channels
decreases cAMP levels
|
|
gptkbp:encodedBy
|
gptkb:HRH3_gene
|
|
gptkbp:enemyOf
|
gptkb:ciproxifan
gptkb:immepip
gptkb:pitolisant
gptkb:thioperamide
clobenpropit
imetit
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
autonomic nervous system
|
|
gptkbp:foundIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
modulates neurotransmitter release
inhibits histamine release
regulates cognition
regulates sleep-wake cycle
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
H3 receptor
|
|
gptkbp:involves
|
gptkb:Alzheimer's_disease
gptkb:attention_deficit_hyperactivity_disorder
epilepsy
schizophrenia
obesity
sleep disorders
pain modulation
narcolepsy
cognitive disorders
|
|
gptkbp:regulates
|
dopamine release
GABA release
acetylcholine release
glutamate release
norepinephrine release
serotonin release
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:targetOfDrug
|
gptkb:betahistine
gptkb:ciproxifan
gptkb:pitolisant
gptkb:thioperamide
clobenpropit
|
|
gptkbp:bfsParent
|
gptkb:antihistamine
|
|
gptkbp:bfsLayer
|
6
|