|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:histaminase
|
|
gptkbp:catalyzes
|
oxidative deamination of diamines
|
|
gptkbp:cofactor
|
gptkb:pyridoxal_phosphate
copper
|
|
gptkbp:deficiencyCauses
|
increased histamine levels
|
|
gptkbp:EC_number
|
1.4.3.22
|
|
gptkbp:enzymeClassification
|
oxidoreductase
|
|
gptkbp:foundIn
|
gptkb:kidney
gptkb:placenta
liver
intestinal mucosa
|
|
gptkbp:function
|
degrades histamine in the gut
|
|
gptkbp:gene
|
gptkb:AOC1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
diamine oxidase
|
|
gptkbp:inhibitedBy
|
gptkb:beer
gptkb:isoniazid
gptkb:aminoguanidine
chloroquine
certain drugs
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:optimum_pH
|
37°C
7.2-7.4
|
|
gptkbp:presentIn
|
gptkb:Bacteria
mammals
plants
|
|
gptkbp:produces
|
hydrogen peroxide
ammonia
aldehyde
|
|
gptkbp:significance
|
histamine intolerance
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:putrescine
gptkb:histamine
cadaverine
|
|
gptkbp:systematicName
|
amine:oxygen oxidoreductase (deaminating)
|
|
gptkbp:used_in
|
food safety testing
diagnosis of histamine intolerance
|
|
gptkbp:bfsParent
|
gptkb:histamine
|
|
gptkbp:bfsLayer
|
7
|