Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:HK2
gptkb:hexokinase_II HK II |
| gptkbp:associatedWith |
cancer metabolism
|
| gptkbp:catalyzes |
phosphorylation of glucose to glucose-6-phosphate
|
| gptkbp:EC_number |
2.7.1.1
|
| gptkbp:encodedBy |
gptkb:HK2_gene
|
| gptkbp:expressedIn |
gptkb:skeletal_muscle
heart liver pancreas adipocytes |
| gptkbp:foundIn |
gptkb:skeletal_muscle
adipose tissue |
| gptkbp:function |
key enzyme in glycolysis
|
| gptkbp:gene |
gptkb:HK2
|
| https://www.w3.org/2000/01/rdf-schema#label |
hexokinase type II
|
| gptkbp:inhibitedBy |
gptkb:glucose-6-phosphate
2-deoxyglucose |
| gptkbp:molecularWeight |
about 100 kDa
|
| gptkbp:regulates |
inhibited by glucose-6-phosphate
stimulated by insulin |
| gptkbp:role |
target for cancer therapy
overexpressed in many cancers |
| gptkbp:structure |
homodimer
|
| gptkbp:subcellularLocation |
outer mitochondrial membrane
|
| gptkbp:bfsParent |
gptkb:hexokinase_II
|
| gptkbp:bfsLayer |
7
|