|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Cu/Zn_superoxide_dismutase
|
|
gptkbp:associatedWith
|
amyotrophic lateral sclerosis
|
|
gptkbp:biologicalProcess
|
response to oxidative stress
superoxide dismutase activity
|
|
gptkbp:cellularComponent
|
cytosol
mitochondrion
|
|
gptkbp:cofactor
|
copper
zinc
|
|
gptkbp:discoveredBy
|
gptkb:Irwin_Fridovich
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:Entrez_Gene_ID
|
6647
|
|
gptkbp:enzymeCommissionNumber
|
1.15.1.1
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
human superoxide dismutase 1
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide radicals
|
|
gptkbp:gene
|
gptkb:SOD1
|
|
gptkbp:geneType
|
protein-coding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hSOD1
|
|
gptkbp:locatedOnChromosome
|
gptkb:21q22.11
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~16 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:A4V
gptkb:D90A
gptkb:G93A
gptkb:H46R
gptkb:I113T
gptkb:E100G
gptkb:G37R
gptkb:G41D
G85R
L144F
V148G
linked to familial ALS
D76Y
G93C
G93D
G93R
G93S
G93V
I149T
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_SOD1
gptkb:yeast_SOD1
|
|
gptkbp:pathway
|
detoxification of reactive oxygen species
|
|
gptkbp:PDB
|
gptkb:1HL5
|
|
gptkbp:postTranslationalModification
|
disulfide bond formation
metal binding
|
|
gptkbp:sequence
|
153 amino acids
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
gptkb:P00441
|
|
gptkbp:bfsParent
|
gptkb:SOD1_gene
gptkb:human_SOD1
|
|
gptkbp:bfsLayer
|
7
|