|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
dwarfism
acromegaly
|
|
gptkbp:binds
|
gptkb:recombinant_human_growth_hormone
|
|
gptkbp:encodedBy
|
gptkb:GHR_gene
|
|
gptkbp:expressedIn
|
gptkb:adipose_tissue
gptkb:cancer
gptkb:bone
gptkb:skin
gptkb:pituitary_gland
gptkb:collagen
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:testis
gptkb:thymus
gptkb:mammary_gland
brain
heart
liver
spleen
pancreas
intestine
|
|
gptkbp:extracellularDomain
|
binds growth hormone
|
|
gptkbp:form
|
homodimer upon ligand binding
|
|
gptkbp:foundIn
|
gptkb:cell_membrane
|
|
gptkbp:function
|
mediates effects of growth hormone
|
|
gptkbp:HGNC_ID
|
4262
|
|
gptkbp:intracellularDomain
|
activates JAK2
|
|
gptkbp:involvedIn
|
gptkb:JAK-STAT_signaling_pathway
cell differentiation
cell proliferation
growth regulation
metabolism regulation
|
|
gptkbp:locatedOnChromosome
|
5p13.1-p12
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Laron_syndrome
|
|
gptkbp:OMIM
|
600946
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
gptkb:right
|
|
gptkbp:PDB
|
gptkb:3HHR
|
|
gptkbp:phosphorylates
|
yes
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:UniProtID
|
P10912
|
|
gptkbp:bfsParent
|
gptkb:HGH
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
growth hormone receptor
|