glial cell line-derived neurotrophic factor

URI: https://gptkb.org/entity/glial_cell_line-derived_neurotrophic_factor
GPTKB entity
Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:GDNF
gptkbp:binds gptkb:RET
gptkb:GFRα1
gptkbp:category gptkb:protein
growth factor
secreted protein
developmental protein
extracellular signaling molecule
gptkbp:discoveredBy Anders Björklund
gptkbp:discoveredIn 1993
gptkbp:Entrez_Gene_ID ENSG00000168621
gptkbp:expressedIn central nervous system
peripheral nervous system
gptkbp:function promotes survival of neurons
supports dopaminergic neurons
supports motor neurons
gptkbp:gene GDNF gene
gptkbp:HGNC_ID 4234
https://www.w3.org/2000/01/rdf-schema#label glial cell line-derived neurotrophic factor
gptkbp:locatedOnChromosome gptkb:chromosome_5p13.1
gptkbp:OMIM 600837
gptkbp:orthologIn mouse Gdnf
rat Gdnf
gptkbp:PDB 2V5E
3FUB
gptkbp:recipient gptkb:GFRα1
RET receptor
gptkbp:regulates kidney development
neurite outgrowth
neuronal differentiation
neuronal survival
enteric nervous system development
gptkbp:relatedTo gptkb:Amyotrophic_lateral_sclerosis
gptkb:Parkinson's_disease
gptkbp:sequence human GDNF precursor: 211 amino acids
gptkbp:structure homodimer
gptkbp:therapeuticPotential neurodegenerative diseases
gptkbp:UniProtID P39905
gptkbp:bfsParent gptkb:Sertoli_cells
gptkb:neurturin
gptkb:GDNF
gptkb:persephin
gptkbp:bfsLayer 6