fibroblast growth factor 23

URI: https://gptkb.org/entity/fibroblast_growth_factor_23
GPTKB entity
Statements (29)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:FGF23
gptkbp:actsOn gptkb:kidney
gptkbp:associatedWith gptkb:tumor-induced_osteomalacia
chronic kidney disease
hypophosphatemic rickets
gptkbp:decreasedIn active vitamin D (calcitriol) levels
serum phosphate levels
gptkbp:discoveredIn 2000
gptkbp:encodedBy FGF23 gene
gptkbp:function regulation of phosphate homeostasis
regulation of vitamin D metabolism
gptkbp:gene FGF23 gene
https://www.w3.org/2000/01/rdf-schema#label fibroblast growth factor 23
gptkbp:inhibitedBy 1-alpha-hydroxylase activity
renal phosphate reabsorption
gptkbp:length 251 amino acids
gptkbp:locatedOnChromosome 12p13.3
gptkbp:memberOf gptkb:fibroblast_growth_factor_family
gptkbp:molecularWeight approximately 32 kDa
gptkbp:mutationAssociatedWith autosomal dominant hypophosphatemic rickets
familial tumoral calcinosis
gptkbp:producedBy osteoblasts
osteocytes
gptkbp:recipient gptkb:FGFR1
Klotho
gptkbp:UniProtID Q9GZV9
gptkbp:bfsParent gptkb:Crysvita
gptkbp:bfsLayer 8