Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:ALXN
|
| gptkbp:activities |
anti-FG F23 monoclonal antibody
|
| gptkbp:approves |
gptkb:2018
gptkb:FDA |
| gptkbp:clinical_trial |
Phase 3
pediatric patients adult patients NC T02915739 NC T02915753 NC T02915766 NC T02915780 NC T02915793 |
| gptkbp:contraindication |
severe renal impairment
active infection hypersensitivity to burosumab |
| gptkbp:current_use |
osteomalacia
hypophosphatemic rickets renal phosphate wasting |
| gptkbp:developed_by |
gptkb:Ultragenyx_Pharmaceutical
|
| gptkbp:dosage_form |
solution for injection
|
| gptkbp:education |
recognizing side effects
proper injection technique importance of regular monitoring |
| gptkbp:formulation |
sterile solution
|
| gptkbp:frequency |
once a month
once every two weeks |
| https://www.w3.org/2000/01/rdf-schema#label |
Crysvita
|
| gptkbp:indication |
X-linked hypophosphatemia in children
|
| gptkbp:ingredients |
gptkb:burosumab
|
| gptkbp:interacts_with |
no significant drug interactions reported
|
| gptkbp:invention |
patented
|
| gptkbp:is_monitored_by |
kidney function
calcium levels serum phosphate levels |
| gptkbp:is_used_for |
treatment of X-linked hypophosphatemia
|
| gptkbp:manager |
subcutaneous injection
|
| gptkbp:marketed_as |
gptkb:legislation
gptkb:Japan gptkb:United_States gptkb:Native_American_tribe |
| gptkbp:packaging |
single-use prefilled syringe
|
| gptkbp:pharmacokinetics |
half-life of approximately 19 days
elimination primarily through the reticuloendothelial system peak plasma concentration at 1-3 days after injection |
| gptkbp:population |
adults
children aged 1 year and older |
| gptkbp:price |
varies by region
|
| gptkbp:receives_funding_from |
covered by some insurance plans
|
| gptkbp:side_effect |
gptkb:fandom
headache injection site reactions thrombocytopenia serious allergic reactions elevated liver enzymes nasopharyngitis hyperphosphatemia |
| gptkbp:status |
ongoing studies
|
| gptkbp:storage |
refrigerated
|
| gptkbp:type_of_care |
important for treatment efficacy
|