|
gptkbp:instanceOf
|
gptkb:brand
gptkb:drug
|
|
gptkbp:activeIngredient
|
gptkb:ezetimibe
gptkb:simvastatin
|
|
gptkbp:approvedBy
|
gptkb:United_States
gptkb:FDA
2004
|
|
gptkbp:ATCCode
|
C10BA02
|
|
gptkbp:combines
|
gptkb:ezetimibe
gptkb:simvastatin
|
|
gptkbp:contraindication
|
gptkb:liver_disease
pregnancy
|
|
gptkbp:drugClass
|
statin
cholesterol absorption inhibitor
|
|
gptkbp:eliminationHalfLife
|
2 hours (simvastatin)
22 hours (ezetimibe)
|
|
gptkbp:form
|
gptkb:tablet
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Vytorin
|
|
gptkbp:indication
|
increase HDL cholesterol
reduce LDL cholesterol
reduce apolipoprotein B
reduce total cholesterol
reduce triglycerides
|
|
gptkbp:interactsWith
|
gptkb:milk
gptkb:cyclosporine
gptkb:warfarin
gptkb:gemfibrozil
gptkb:verapamil
niacin
amiodarone
diltiazem
|
|
gptkbp:legalStatus
|
Rx-only
|
|
gptkbp:marketedAs
|
gptkb:Merck_&_Co.
|
|
gptkbp:mechanismOfAction
|
inhibits cholesterol absorption and synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:patentExpired
|
2017
|
|
gptkbp:pregnancyCategory
|
X
|
|
gptkbp:prescriptionStatus
|
prescription only
|
|
gptkbp:riskFactor
|
muscular dystrophy
rhabdomyolysis
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
abdominal pain
headache
muscle pain
liver enzyme abnormalities
|
|
gptkbp:usedFor
|
gptkb:familial_hypercholesterolemia
dyslipidemia
|
|
gptkbp:bfsParent
|
gptkb:Merck_&_Co.
|
|
gptkbp:bfsLayer
|
4
|