Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
cholesterol absorption inhibitor |
| gptkbp:approvalYear |
2002
|
| gptkbp:approvedBy |
gptkb:FDA
|
| gptkbp:ATCCode |
gptkb:C10AX09
|
| gptkbp:brand |
gptkb:Ezetrol
gptkb:Zetia |
| gptkbp:CASNumber |
gptkb:163222-33-1
|
| gptkbp:combines |
gptkb:atorvastatin
gptkb:simvastatin |
| gptkbp:contraindication |
pregnancy
breastfeeding active liver disease |
| gptkbp:developedBy |
gptkb:Schering-Plough
|
| gptkbp:drugClass |
lipid-lowering agent
|
| gptkbp:eliminationHalfLife |
22 hours
|
| gptkbp:excretion |
urine
feces |
| gptkbp:hasMolecularFormula |
C24H21F2NO3
|
| https://www.w3.org/2000/01/rdf-schema#label |
Ezetimibum
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
inhibits NPC1L1 protein
|
| gptkbp:metabolism |
liver
intestine |
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
diarrhea
abdominal pain fatigue elevated liver enzymes |
| gptkbp:usedFor |
gptkb:familial_hypercholesterolemia
gptkb:sitosterolemia |
| gptkbp:bfsParent |
gptkb:ezetimibe
|
| gptkbp:bfsLayer |
6
|