exchange protein directly activated by cAMP
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:EPAC
|
| gptkbp:activatedBy |
cyclic AMP
|
| gptkbp:alternativeName |
cAMP-regulated guanine nucleotide exchange factor
|
| gptkbp:discoveredBy |
1998
|
| gptkbp:expressedIn |
various tissues
|
| gptkbp:function |
mediates cAMP signaling independent of PKA
|
| gptkbp:gene |
gptkb:RAPGEF3
gptkb:RAPGEF4 |
| https://www.w3.org/2000/01/rdf-schema#label |
exchange protein directly activated by cAMP
|
| gptkbp:inhibitedBy |
gptkb:CE3F4
gptkb:ESI-09 |
| gptkbp:mechanismOfAction |
acts as guanine nucleotide exchange factor for Rap1 and Rap2
|
| gptkbp:member |
gptkb:EPAC1
gptkb:EPAC2 |
| gptkbp:orthologIn |
found in mammals
|
| gptkbp:relatedTo |
gptkb:protein_kinase_A
gptkb:cAMP_signaling_pathway |
| gptkbp:role |
cancer progression
inflammation learning and memory cell adhesion cell junction formation insulin secretion neuronal signaling cardiac function |
| gptkbp:structure |
contains CDC25-homology domain
contains cAMP-binding domain |
| gptkbp:bfsParent |
gptkb:cAMP_signaling_pathway
|
| gptkbp:bfsLayer |
7
|