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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
|
EIF2S1 protein
eukaryotic translation initiation factor 2 subunit alpha
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gptkbp:function
|
regulation of translation initiation
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gptkbp:gene
|
EIF2S1
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https://www.w3.org/2000/01/rdf-schema#label
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eIF2α
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gptkbp:inhibitedBy
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global protein synthesis upon phosphorylation
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gptkbp:interactsWith
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gptkb:eIF2B
eIF2β
eIF2γ
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gptkbp:involvedIn
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gptkb:integrated_stress_response
unfolded protein response
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gptkbp:locatedOnChromosome
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gptkb:human_chromosome_14q24.3
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gptkbp:location
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gptkb:cytoplasm
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gptkbp:molecularWeight
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36 kDa
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gptkbp:mutationAssociatedWith
|
vanishing white matter disease
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gptkbp:orthologIn
|
yeast SUI2
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gptkbp:partOf
|
eukaryotic initiation factor 2
|
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gptkbp:phosphorylates
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gptkb:HRI
gptkb:PERK
PKR
GCN2
Serine 51
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gptkbp:regulates
|
phosphorylation-dependent
translation of ATF4 mRNA
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gptkbp:role
|
mediates stress-induced translational control
|
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gptkbp:species
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gptkb:Mus_musculus
gptkb:Homo_sapiens
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gptkbp:structure
|
contains N-terminal and C-terminal domains
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gptkbp:UniProtID
|
P05198
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gptkbp:bfsParent
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gptkb:PPP1R15A
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gptkbp:bfsLayer
|
7
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