|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:AADC
aromatic L-amino acid decarboxylase
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
gptkb:AADC_deficiency
|
|
gptkbp:biologicalProcess
|
catalytic activity
aromatic-L-amino-acid decarboxylase activity
dopamine biosynthetic process
serotonin biosynthetic process
|
|
gptkbp:catalyzes
|
decarboxylation of 5-HTP to serotonin
decarboxylation of L-DOPA to dopamine
|
|
gptkbp:cofactor
|
gptkb:pyridoxal_phosphate
|
|
gptkbp:EC_number
|
4.1.1.28
|
|
gptkbp:encodedBy
|
gptkb:DDC_gene
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
liver
pancreas
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:gene
|
gptkb:DDC
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
dopa decarboxylase
|
|
gptkbp:inhibitedBy
|
benserazide
carbidopa
|
|
gptkbp:inhibitor_used_in_therapy
|
benserazide
carbidopa
|
|
gptkbp:involves
|
dopamine biosynthesis
serotonin biosynthesis
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p12.2
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~54 kDa
|
|
gptkbp:OMIM
|
107930
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:pathway
|
gptkb:tryptophan_metabolism
catecholamine biosynthesis
|
|
gptkbp:PDB
|
1JS3
3RBF
|
|
gptkbp:product
|
dopamine
serotonin
|
|
gptkbp:proteinFamily
|
pyridoxal-dependent decarboxylase family
|
|
gptkbp:significance
|
target for Parkinson's disease treatment
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:L-DOPA
gptkb:5-hydroxytryptophan
|
|
gptkbp:UniProtID
|
P20711
|
|
gptkbp:bfsParent
|
gptkb:P5P
|
|
gptkbp:bfsLayer
|
8
|