|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
produces different isoforms
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:myasthenia_gravis
organophosphate poisoning
|
|
gptkbp:cofactor
|
gptkb:water
|
|
gptkbp:EC_number
|
3.1.1.7
|
|
gptkbp:family
|
gptkb:carboxylesterase_family
|
|
gptkbp:foundIn
|
central nervous system
neuromuscular junctions
red blood cell membranes
|
|
gptkbp:fullName
|
gptkb:acetylcholinesterase
|
|
gptkbp:function
|
breaks down acetylcholine
|
|
gptkbp:gene
|
gptkb:ACHE_gene
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ACHE
|
|
gptkbp:inhibitedBy
|
gptkb:organophosphates
carbamates
|
|
gptkbp:inhibitorDrug
|
gptkb:donepezil
gptkb:rivastigmine
galantamine
|
|
gptkbp:locatedOnChromosome
|
7q22.1
|
|
gptkbp:molecularWeight
|
~70 kDa
|
|
gptkbp:PDB
|
gptkb:1B41
|
|
gptkbp:product
|
gptkb:choline
acetate
|
|
gptkbp:significance
|
target for Alzheimer's disease drugs
target for nerve agents
|
|
gptkbp:structure
|
serine hydrolase
|
|
gptkbp:substrate
|
gptkb:acetylcholine
|
|
gptkbp:UniProtID
|
gptkb:P22303
|
|
gptkbp:bfsParent
|
gptkb:Cholinesterase
|
|
gptkbp:bfsLayer
|
6
|